Lutropin-choriogonadotropic hormone receptor (Lhcgr) Recombinant Protein | Lhcgr recombinant protein
Recombinant Mouse Lutropin-choriogonadotropic hormone receptor (Lhcgr)
NCBI and Uniprot Product Information
Uniprot Description
LHR: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in LHCGR are a cause of familial male precocious puberty (FMPP); also known as testotoxicosis. In FMPP the receptor is constitutively activated. Defects in LHCGR are the cause of luteinizing hormone resistance (LHR); also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral
Cellular Component: extracellular space; membrane; endoplasmic reticulum; integral to plasma membrane; lysosome; cytoplasm; integral to membrane; plasma membrane; nucleus; receptor complex; endosome
Molecular Function: lutropin-choriogonadotropic hormone receptor activity; G-protein coupled receptor activity; identical protein binding; signal transducer activity; protein homodimerization activity; peptide hormone binding; protein-hormone receptor activity; peptide receptor activity, G-protein coupled; ATPase binding
Biological Process: protein targeting to lysosome; hormone-mediated signaling; male gonad development; adenylate cyclase activation; positive regulation of calcium-mediated signaling; positive regulation of inositol trisphosphate biosynthetic process; luteinizing hormone signaling pathway; arachidonic acid secretion; uterus development; signal transduction; G-protein signaling, coupled to cAMP nucleotide second messenger; ovulation cycle process; G-protein coupled receptor protein signaling pathway; ovarian follicle development; positive regulation of hormone biosynthetic process; development of secondary male sexual characteristics; spermatogenesis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of release of sequestered calcium ion into cytosol; cognition; female gonad development
Research Articles on Lhcgr
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Product Notes
The Lhcgr lhcgr (Catalog #AAA952688) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 27-700. The amino acid sequence is listed below: PELSGSRCPE PCDCAPDGAL RCPGPRAGLA RLSLTYLPVK VIPSQAFRGL NEVVKIEISQ SDSLERIEAN AFDNLLNLSE ILIQNTKNLL YIEPGAFTNL PRLKYLSICN TGIRTLPDVS KISSSEFNFI LEICDNLYIT TIPGNAFQGM NNESITLKLY GNGFEEVQSH AFNGTTLISL ELKENIYLEK MHSGTFQGAT GPSILDVSST KLQALPSHGL ESIQTLIATS SYSLKTLPSR EKFTSLLVAT LTYPSHCCAF RNLPKKEQNF SFSIFENFSK QCESTVREAN NETLYSAIFE ENELSGWDYD YDFCSPKTLQ CTPEPDAFNP CEDIMGYAFL RVLIWLINIL AIFGNLTVLF VLLTSRYKLT VPRFLMCNLS FADFCMGLYL LLIASVDSQT KGQYYNHAID WQTGSGCSAA GFFTVFASEL SVYTLTVITL ERWHTITYAV QLDQKLRLRH AIPIMLGGWI FSTLMATLPL VGVSSYMKVS ICLPMDVEST LSQVYILSIL LLNAVAFVVI CACYVRIYFA VQNPELTAPN KDTKIAKKMA ILIFTDFTCM APISFFAISA AFKVPLITVT NSKVLLVLFY PVNSCANPFL YAVFTKAFQR DFFLLLSRFG CCKHRAELYR RKEFSACTFN SKNGFPRSSK PSQAALKLSI VHCQQPTPPR VLIQ. It is sometimes possible for the material contained within the vial of "Lutropin-choriogonadotropic hormone receptor (Lhcgr), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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