Galectin-1 Recombinant Protein | mLGALS1 recombinant protein

Recombinant Mouse Galectin-1

Cat. Num. AAA145723

• Gene Names: Lgals1; L14; Gal-1; Galbp; L-14.5; Lect14; AA410090; galectin-1
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Galectin-1; Recombinant Mouse Galectin-1; LGALS1 Mouse; Galectin-1 Mouse Recombinant; Gal-1; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; S-Lac lectin 1; Lgals1; Gbp; L14; Galbp; L-14.5; Lect14; AA410090; mLGALS1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: The LGALS1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMACGLV ASNLNLKPGE CLKVRGEVAS DAKSFVLNLG KDSNNLCLHF NPRFNAHGDA NTIVCNTKED GTWGTEHREP AFPFQPGSIT EVCITFDQAD LTIKLPDGHE FKFPNRLNME AINYMAADGD FKIKCVAFE.
• Sequence Length: 135

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for mLGALS1 recombinant protein

Description: LGALS1 mouse Recombinant produced E Coli is a single polypeptide chain containing 159 amino acids (1-135) and having a molecular mass of 17kDa.LGALS1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 is an autocrine negative growth factor that regulates cell proliferation. Galectin-1 regulates cell apoptosis and cell differentiation. Galectin-1 binds CD45, CD3 and CD4 & inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of lyn kinase. Galectin-1 and its ligands are one of the master regulators of immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as hostpathogen interactions. Galectin-1 expression or overexpression in tumors and/or the tissue surrounding them must be considered as a sign of the malignant tumor progression that is often related to the long-range dissemination of tumoral cells (metastasis), to their dissemination into the surrounding normal tissue, and to tumor immune-escape. Galectin-1 in its oxidized form plays a number of important roles in the regeneration of the central nervous system after injury. The targeted overexpression (or delivery) of Galectin-1 should be considered as a method of choice for the treatment of some kinds of inflammation-related diseases, neurodegenerative pathologies and muscular dystrophies. In contrast, the targeted inhibition of Galectin-1 expression is what should be developed for therapeutic applications against cancer progression. Galectin-1 is thus a promising molecular target for the development of new and original therapeutic tools. There is 88% homology between the human and mouse galectin-1.

Product Categories/Family for mLGALS1 recombinant protein

Cytokines and Growth Factors; Growth Factors; Galectin

NCBI and Uniprot Product Information

• NCBI GI #: 6678682
• NCBI GeneID: 16852
• NCBI Accession #: NP_032521.1
• NCBI GenBank Nucleotide #: NM_008495.2
• UniProt Accession #: P16045; P05163; P11946; P17601; Q4FZH4; Q99M27; Q9D0X0
• Molecular Weight: 14,866 Da
• NCBI Official Full Name: galectin-1
• NCBI Official Synonym Full Names: lectin, galactose binding, soluble 1
• NCBI Official Symbol: Lgals1
• NCBI Official Synonym Symbols: L14; Gal-1; Galbp; L-14.5; Lect14; AA410090; galectin-1
• NCBI Protein Information: galectin-1; 14 kDa lectin; S-Lac lectin 1; beta-galactoside binding protein; beta-galactoside-binding lectin L-14-I; galaptin; lactose-binding lectin 1; lectin galactoside-binding soluble 1
• UniProt Protein Name: Galectin-1
• Protein Family: Galectin
• UniProt Gene Name: Lgals1
• UniProt Synonym Gene Names: Gbp; Gal-1
• UniProt Entry Name: LEG1_MOUSE

Uniprot Description

Galectin-1: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N- acetyllactosamine). Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion. Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.

Protein type: Cell adhesion

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; cell surface; cytoplasm; extracellular region; intracellular; nucleus

Molecular Function: signal transducer activity; protein binding; protein homodimerization activity; lactose binding; galactose binding; laminin binding; galactoside binding; carbohydrate binding; glycoprotein binding

Biological Process: heterophilic cell adhesion; myoblast differentiation; positive regulation of I-kappaB kinase/NF-kappaB cascade; plasma cell differentiation; apoptosis; T cell costimulation; positive regulation of erythrocyte aggregation; signal transduction