Mouse leucine proline-enriched proteoglycan (leprecan) 1 ELISA Kit | LEPRE1 elisa kit
Mouse Prolyl 3-hydroxylase 1, LEPRE1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
LEPRE1: Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. Defects in LEPRE1 are the cause of osteogenesis imperfecta type 8 (OI8). A connective tissue disorder characterized by disproportionate short stature, severe osteoporosis, shortening of the long bones, white sclerae, a round face and a short barrel-shaped chest. Belongs to the leprecan family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide; Oxidoreductase; EC 1.14.11.7
Cellular Component: proteinaceous extracellular matrix; membrane; endoplasmic reticulum; cytoplasm; extracellular region; plasma membrane; basement membrane; nucleus
Molecular Function: procollagen-proline 3-dioxygenase activity; dioxygenase activity; L-ascorbic acid binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity
Biological Process: regulation of protein secretion; collagen fibril organization; protein folding; protein stabilization; collagen metabolic process; peptidyl-proline hydroxylation; protein amino acid hydroxylation; regulation of ossification; cell growth
Research Articles on LEPRE1
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Product Notes
The Mouse LEPRE1 lepre1 (Catalog #AAA9341001) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341001 ELISA Kit recognizes Mouse LEPRE1. It is sometimes possible for the material contained within the vial of "leucine proline-enriched proteoglycan (leprecan) 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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