Linker For Activation Of T-Cells Family, Member 2 (LAT2) Recombinant Protein | LAT2 recombinant protein

Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2)

Cat. Num. AAA2018781

• Gene Names: LAT2; LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Linker For Activation Of T-Cells Family; Member 2 (LAT2); Recombinant Linker For Activation Of T-Cells Family; LAT2 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.; MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- R PGAKRSEKIY QQRSLREDQQ SFTGSRTYSL VGQAWPGPLA DMAPTRKDKL LQFYPSLEDP ASSRYQNFSK GSRHGSEEAY IDPIAMEYYN WGRFSKPPED DDANSYENVL ICKQKTTETG AQQEGIGGLC RGDLSLSLALKTGPTSGLCP SASPEEDEES EDYQNSASIH QWRESRKVM
• Sequence Length: 243

• Applicable Applications for LAT2 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Homo sapiens (Human)
• Expression System: Prokaryotic expression
• Residues: Arg30~Met209 (Accession # Q9GZY6) with two N-terminal Tags, His-tag and T7-tag
• Subcellular Location: Cell membrane; Single-pass type III membrane protein
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Predicted Isoelectric Point: 6.1
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 14702182
• NCBI GeneID: 7462
• NCBI Accession #: NP_054865.2
• NCBI GenBank Nucleotide #: NM_014146.3
• UniProt Accession #: Q9GZY6; Q9BXX8; Q9NZY9; A6NFK6; A8K209; A8K4F1; D3DXF9
• Molecular Weight: 24.0kDa
• NCBI Official Full Name: linker for activation of T-cells family member 2
• NCBI Official Synonym Full Names: linker for activation of T cells family, member 2
• NCBI Official Symbol: LAT2
• NCBI Official Synonym Symbols: LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
• NCBI Protein Information: linker for activation of T-cells family member 2; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2
• UniProt Protein Name: Linker for activation of T-cells family member 2
• Protein Family: Linker for activation of T-cells family
• UniProt Gene Name: LAT2
• UniProt Synonym Gene Names: LAB; NTAL; WBS15; WBSCR15; WBSCR5
• UniProt Entry Name: NTAL_HUMAN

NCBI Description

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: mast cell granule; plasma membrane; integral to membrane; lipid raft

Molecular Function: protein binding; SH2 domain binding

Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation