LAMP2 / CD107b recombinant protein

Recombinant Mouse LAMP2 / CD107b Protein (His tag)

Cat. Num. AAA2546789

• Gene Names: Lamp2; Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c
• Purity: > 97 % as determined by SDS-PAGE
• Synonyms: LAMP2 / CD107b; Recombinant Mouse LAMP2 / CD107b Protein (His tag); RP23-193O17.2; CD107b; Lamp-2; Lamp-2a; Lamp-2b; Lamp-2c; Mac3; LAMP2 / CD107b recombinant protein

• Host: Human Cells
• Purity/Purification: > 97 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 415

• Application Notes: The secreted recombinant mouse LAMP2 comprises 365 amino acids and has a calculated molecular mass of 40.6 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 70-80 kDa band in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Leu 26
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for LAMP2 / CD107b recombinant protein

Background: LAMP2 (Lysosomal-associated membrane protein 2), also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. In human, LAMP2, the causative gene of Danon disease, located on chromosome Xq24, encodes the lysosome-associated membrane protein-2 (LAMP-2). LAMP-2 deficiency, or Danon disease, is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy.

Description: A DNA sequence encoding the mouse LAMP2 (P17047-1) extracellular domain (Leu 26-Asn 379) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 63054837
• NCBI GeneID: 16784
• NCBI Accession #: NP_001017959.1
• NCBI GenBank Nucleotide #: NM_001017959.2
• UniProt Accession #: P17047; Q3TXG5; Q8BSG8; A2A430
• Molecular Weight: 45,655 Da
• NCBI Official Full Name: lysosome-associated membrane glycoprotein 2 isoform 1
• NCBI Official Synonym Full Names: lysosomal-associated membrane protein 2
• NCBI Official Symbol: Lamp2
• NCBI Official Synonym Symbols: Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c
• NCBI Protein Information: lysosome-associated membrane glycoprotein 2
• UniProt Protein Name: Lysosome-associated membrane glycoprotein 2
• UniProt Gene Name: Lamp2
• UniProt Synonym Gene Names: Lamp-2; LAMP-2; Lysosome-associated membrane protein 2; LGP-B

Uniprot Description

LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: X A3.3|X 22.67 cM

Cellular Component: endosome; extracellular space; late endosome; late endosome membrane; lipid raft; lysosomal membrane; lysosome; membrane; phagocytic vesicle membrane; platelet dense granule membrane

Molecular Function: enzyme binding; protein domain specific binding

Biological Process: muscle maintenance; protein stabilization; regulation of protein stability