KLRC2 recombinant protein

KLRC2, human recombinant

Cat. Num. AAA844167

• Gene Names: KLRC2; NKG2C; CD159c; NKG2-C
• Applications: SDS-Page
• Purity: >=85%
• Synonyms: KLRC2; human recombinant; NKG2-C type II integral membrane protein; CD159c; NKG2-C; NKG2C; KLRC2 recombinant protein

• Host: E Coli
• Purity/Purification: >=85%
• Form/Format: 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.; Appearance: Liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSM IPFLEQ NNFSPNTRTQ KARHCGHCPE EWITYSNSCY YIGKERRTWE ESLLACTSKN SSLLSIDNEE EMKFLASILP SSWIGVFRNS SHHPWVTING LAFKHKIKDS DNAELNCAVL QVNRLKSAQC GSSMIYHCKH KL
• Sequence Length: 231

• Applicable Applications for KLRC2 recombinant protein: SDS-PAGE
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -80 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for KLRC2 recombinant protein

Background: NKG2-C type II integral membrane protein, also known as KLRC2, plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. Recombinant human KLRC2 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Product Categories/Family for KLRC2 recombinant protein

Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Proteins and Enzymes (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 75709169
• NCBI GeneID: 3822
• NCBI Accession #: NP_002251.2
• NCBI GenBank Nucleotide #: NM_002260.3
• UniProt Accession #: P26717; O43802; Q52M74; Q9NR42
• Molecular Weight: 18.4 kDa (162 aa, 94-231 aa + His Tag), confirmed by MALDI-TOF.
• NCBI Official Full Name: NKG2-C type II integral membrane protein
• NCBI Official Synonym Full Names: killer cell lectin-like receptor subfamily C, member 2
• NCBI Official Symbol: KLRC2
• NCBI Official Synonym Symbols: NKG2C; CD159c; NKG2-C
• NCBI Protein Information: NKG2-C type II integral membrane protein
• UniProt Protein Name: NKG2-C type II integral membrane protein
• Protein Family: NKG2-C type II integral membrane protein
• UniProt Gene Name: KLRC2
• UniProt Synonym Gene Names: NKG2C
• UniProt Entry Name: NKG2C_HUMAN

NCBI Description

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

KLRC2: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; transmembrane receptor activity; carbohydrate binding

Biological Process: natural killer cell mediated immunity; innate immune response; cellular defense response; signal transduction