Kallikrein-7 Recombinant Protein | KLK7 recombinant protein

Recombinant Human Kallikrein-7 protein

Cat. Num. AAA9422362

• Gene Names: KLK7; hK7; SCCE; PRSS6
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Kallikrein-7; Recombinant Human Kallikrein-7 protein; Serine protease 6Stratum corneum chymotryptic enzyme; hSCCE; KLK7 recombinant protein

• Host: Yeast
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 28-253aa

• Tag Info: NO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for KLK7 recombinant protein

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.

NCBI and Uniprot Product Information

• NCBI GI #: 333609286
• NCBI GeneID: 5650
• NCBI Accession #: NP_001193982.1
• NCBI GenBank Nucleotide #: NM_001207053.1
• UniProt Accession #: P49862; Q8N5N9; Q8NFV7; A8K0U5
• Molecular Weight: 26.4kD
• NCBI Official Full Name: kallikrein-7 isoform 2
• NCBI Official Synonym Full Names: kallikrein related peptidase 7
• NCBI Official Symbol: KLK7
• NCBI Official Synonym Symbols: hK7; SCCE; PRSS6
• NCBI Protein Information: kallikrein-7
• UniProt Protein Name: Kallikrein-7
• Protein Family: Kallikrein
• UniProt Gene Name: KLK7
• UniProt Synonym Gene Names: PRSS6; SCCE; hK7; hSCCE

NCBI Description

This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

Uniprot Description

KLK7: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.35; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region; extracellular space

Molecular Function: metalloendopeptidase activity; peptidase activity; serine-type peptidase activity

Biological Process: epidermis development; extracellular matrix disassembly; positive regulation of antibacterial peptide production