Kallikrein 4/KLK4 Recombinant Protein | KLK4 recombinant protein

Recombinant Human Kallikrein 4/KLK4 Protein (C-6His)

Cat. Num. AAA2552877

• Gene Names: KLK4; ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Synonyms: Kallikrein 4/KLK4; Recombinant Human Kallikrein 4/KLK4 Protein (C-6His); Kallikrein-4; Enamel Matrix Serine Proteinase 1; Kallikrein-Like Protein 1; KLKL1; Prostase; Serine Protease 17; KLK4; EMSP1; PRSS17; PSTS; AI2A1; ARM1; EMSP; kallikrein; KLK-L1; KLK4 recombinant protein

• Host: Human Cells
• Purity/Purification: > 95 % as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
• Sequence Positions: Ser27-Ser254
• Sequence Length: 159

• Species: Human
• Endotoxin: < 1.0 EU per ug as determined by the LAL method.
• Tag: C-6His
• Reconstitution: We recommend that the vial be centrifuged to opening to bring the contents to the bottom. Do not mix by vortex.It is recommended that sterile water(200ul) be added to the vial to prepare a stock solution of 0.25mg/mL. Concentration is measured by UV-Vis.
• Preparation and Storage: Lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; ; Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

SDS-PAGE (SDS)

Related Product Information for KLK4 recombinant protein

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen members of the Kallikrein subfamily located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.

NCBI and Uniprot Product Information

• NCBI GI #: 729042255
• NCBI GeneID: 9622
• NCBI Accession #: NP_001289890.1
• NCBI GenBank Nucleotide #: NM_001302961.1
• UniProt Accession #: Q9Y5K2; Q4VB16; Q96RU5; Q9GZL6; Q9UBJ6
• Molecular Weight: Mol_Mass: 25.44 kDa; AP_Mol_Mass: 25-32 kDa
• NCBI Official Full Name: kallikrein-4 isoform 2
• NCBI Official Synonym Full Names: kallikrein related peptidase 4
• NCBI Official Symbol: KLK4
• NCBI Official Synonym Symbols: ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein
• NCBI Protein Information: kallikrein-4
• UniProt Protein Name: Kallikrein-4
• Protein Family: Kallikrein
• UniProt Gene Name: KLK4
• UniProt Synonym Gene Names: EMSP1; PRSS17; PSTS; KLK-L1

NCBI Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Description

Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix ().