Mouse Kruppel-like factor 1 (erythroid) ELISA Kit | KLF1 elisa kit
Mouse Krueppel-like factor 1, KLF1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
KLF1: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. Defects in KLF1 are the cause of congenital dyserythropoietic anemia type 4 (CDA4). It is a blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin. Belongs to the krueppel C2H2-type zinc-finger protein family.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Cellular Component: nuclear chromatin; nucleus
Molecular Function: protein domain specific binding; transcription activator binding; nucleic acid binding; DNA binding; metal ion binding
Biological Process: chromatin remodeling; erythrocyte development; erythrocyte maturation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; embryonic hemopoiesis; in utero embryonic development; positive regulation of transcription, DNA-dependent; erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; liver development
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Product Notes
The Mouse KLF1 klf1 (Catalog #AAA9342956) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342956 ELISA Kit recognizes Mouse KLF1. It is sometimes possible for the material contained within the vial of "Kruppel-like factor 1 (erythroid), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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