Mast/stem cell growth factor receptor Kit (KIT) Recombinant Protein | KIT recombinant protein

Recombinant Dog Mast/stem cell growth factor receptor Kit (KIT), partial

Cat. Num. AAA1258942

• Gene Names: KIT; c-KIT
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Mast/stem cell growth factor receptor Kit (KIT); Recombinant Dog Mast/stem cell growth factor receptor Kit (KIT); partial; KIT recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 28-527
• Sequence: QPS VSPGEPSLPS IHPAKSELIV SVGDELRLSC TDPGFVKWTF ETLGQLNENT HNEWITEKAE AGHTGNYTCT NRDGLSRSIY VFVRDPAKLF LVDLPLYGKE GNDTLVRCPL TDPEVTNYSL RGCEGKPLPK DLTFVADPKA GITIRNVKRE YHRLCLHCSA DQKGRTVLSK KFTLKVRAAI RAVPVVSVSK TSSLLKEGEA FSVMCFIKDV SSFVDSMWIK ENSQQTNAQT QSNSWHHGDF NFERQEKLII SSARVNDSGV FMCYANNTFG SANVTTTLEV VDKGFINIFP MMSTTIFVND GENVDLIVEY EAYPKPEHQQ WIYMNRTFTD KWEDYPKSDN ESNIRYVSEL HLTRLKGNEG GTYTFQVSNS DVNSSVTFNV YVNTKPEILT HESLTNGMLQ CVVAGFPEPA VDWYFCPGAE QRCSVPIGPM DVQMQNSSLS PSGKLVVQSS IDYSAFKHNG TVECRAYNNV GRSSAFFNFA FKGNSKEQIH PHTLFTP
• Sequence Length: 500

• Species: Canis familiaris (Dog) (Canis lupus familiaris)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for KIT recombinant protein

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 50978928
• NCBI GeneID: 403811
• NCBI Accession #: NP_001003181.1
• NCBI GenBank Nucleotide #: NM_001003181.1
• UniProt Accession #: O97799; Q7YRV7; Q8WN23
• Molecular Weight: 109,367 Da
• NCBI Official Full Name: mast/stem cell growth factor receptor Kit
• NCBI Official Synonym Full Names: KIT proto-oncogene receptor tyrosine kinase
• NCBI Official Symbol: KIT
• NCBI Official Synonym Symbols: c-KIT
• NCBI Protein Information: mast/stem cell growth factor receptor Kit
• UniProt Protein Name: Mast/stem cell growth factor receptor Kit
• Protein Family: Mast/stem cell growth factor receptor
• UniProt Gene Name: KIT
• UniProt Synonym Gene Names: SCFR

Uniprot Description

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 ().