Lysine-specific demethylase 5A Recombinant Protein | KDM5A recombinant protein

Recombinant Human Lysine-specific demethylase 5A

Cat. Num. AAA9422360

• Gene Names: KDM5A; RBP2; RBBP2; RBBP-2
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Lysine-specific demethylase 5A; Recombinant Human Lysine-specific demethylase 5A; Histone demethylase JARID1AJumonji/ARID domain-containing protein 1ARetinoblastoma-binding protein 2; RBBP-2; KDM5A recombinant protein

• Host: Yeast
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: JmjC, 437-603aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for KDM5A recombinant protein

Histone dethylase that specifically dethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not dethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Dethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone dethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1.

NCBI and Uniprot Product Information

• NCBI GI #: 110618244
• NCBI GeneID: 5927
• NCBI Accession #: NP_001036068.1
• NCBI GenBank Nucleotide #: NM_001042603.2
• UniProt Accession #: P29375; Q4LE72; Q86XZ1; A8MV76
• Molecular Weight: 21.3kD
• NCBI Official Full Name: lysine-specific demethylase 5A
• NCBI Official Synonym Full Names: lysine demethylase 5A
• NCBI Official Symbol: KDM5A
• NCBI Official Synonym Symbols: RBP2; RBBP2; RBBP-2
• NCBI Protein Information: lysine-specific demethylase 5A
• UniProt Protein Name: Lysine-specific demethylase 5A
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: KDM5A
• UniProt Synonym Gene Names: JARID1A; RBBP2; RBP2; RBBP-2

NCBI Description

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

Uniprot Description

JARID1A: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Interacts with SUZ12; the interaction is direct. Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor

Chromosomal Location of Human Ortholog: 12p13.33

Cellular Component: cyclin-dependent protein kinase activating kinase holoenzyme complex; nucleoplasm; nucleus

Molecular Function: DNA binding; histone demethylase activity; histone demethylase activity (H3-K9 specific); protein binding; transcription coactivator activity; transcription factor activity

Biological Process: circadian regulation of gene expression; histone H3-K9 demethylation; positive regulation of transcription, DNA-dependent; regulation of transcription factor activity; transcription from RNA polymerase II promoter