KDM2B recombinant protein

KDM2B Protein

Cat. Num. AAA517155

• Gene Names: KDM2B; CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
• Applications: Western Blot
• Synonyms: KDM2B; KDM2B Protein; FBXL10; CXXC2; Fbl10; JHDM1B; PCCX2; KDM2B recombinant protein

• Host: Sf9 insect cells
• Form/Format: Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

• Applicable Applications for KDM2B recombinant protein: Western Blot (WB)
• Tag: GST
• Species: Human
• Preparation and Storage: Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

SDS-Page

(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)

Related Product Information for KDM2B recombinant protein

Recombinant full-length human KDM2B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is BC115380.
KDM2B is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box proteins which constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination (1). KDM2B functions in a DNA repair process other than mismatch repair. KDM2B is highly expressed in aggressive brain tumors, which play a main role in cancer development (2). KDM2B is a key regulator of JUN function.

Product Categories/Family for KDM2B recombinant protein

Deacetylase & Demethylase Proteins; Cancer; Cell Cycle; Inflammation

References

1.Frescas, D. et.al: JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature 450: 309-313, 2007.
2.Jin, J. et al: Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 18: 2573-2580, 2004.

NCBI and Uniprot Product Information

• NCBI GI #: 92098160
• NCBI GeneID: 84678
• Molecular Weight: 151KD
• NCBI Official Full Name: Homo sapiens F-box and leucine-rich repeat protein 10, mRNA
• NCBI Official Synonym Full Names: lysine demethylase 2B
• NCBI Official Symbol: KDM2B
• NCBI Official Synonym Symbols: CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
• NCBI Protein Information: lysine-specific demethylase 2B
• Protein Family: Lysine-specific demethylase

NCBI Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]