Lysine-specific demethylase 2B (KDM2B) Recombinant Protein | KDM2B recombinant protein

Recombinant Human Lysine-specific demethylase 2B (KDM2B) , partial

• Gene Names: KDM2B; CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Lysine-specific demethylase 2B (KDM2B); Recombinant Human Lysine-specific demethylase 2B (KDM2B); partial; KDM2B recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 559

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for KDM2B recombinant protein

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 54112380
• NCBI GeneID: 84678
• NCBI Accession #: NP_001005366.1
• NCBI GenBank Nucleotide #: NM_001005366.1
• UniProt Accession #: Q8NHM5; Q1RLM7; Q8NCI2; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75; A8MRS1
• Molecular Weight: 63,630 Da
• NCBI Official Full Name: lysine-specific demethylase 2B isoform b
• NCBI Official Synonym Full Names: lysine demethylase 2B
• NCBI Official Symbol: KDM2B
• NCBI Official Synonym Symbols: CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
• NCBI Protein Information: lysine-specific demethylase 2B
• UniProt Protein Name: Lysine-specific demethylase 2B
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: KDM2B
• UniProt Synonym Gene Names: CXXC2; FBL10; FBXL10; JHDM1B; PCCX2; Protein JEMMA

NCBI Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.