ATP-sensitive inward rectifier potassium channel 10 (Kcnj10) Recombinant Protein | Kcnj10 recombinant protein
Recombinant Rat ATP-sensitive inward rectifier potassium channel 10 (Kcnj10)
NCBI and Uniprot Product Information
NCBI Description
inwardly rectifying K+ channel; specifically expressed in brain [RGD, Feb 2006]
Uniprot Description
Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
Protein type: Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: microvillus; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: identical protein binding; protein binding; potassium channel activity; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; ATP binding; receptor binding
Biological Process: regulation of long-term neuronal synaptic plasticity; myelination in the central nervous system; response to glucocorticoid stimulus; membrane hyperpolarization; response to blue light; glutamate uptake during transmission of nerve impulse; response to mineralocorticoid stimulus; adult walking behavior; protein homotetramerization; L-glutamate import; regulation of membrane potential; potassium ion import; visual perception; optic nerve development; regulation of resting membrane potential; regulation of sensory perception of pain; inflammatory response; oligodendrocyte development; potassium ion homeostasis; potassium ion transport
Research Articles on Kcnj10
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Product Notes
The Kcnj10 kcnj10 (Catalog #AAA948201) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-379. The amino acid sequence is listed below: MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVAYH NGKLCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY LPEEILWGYE FTPAISLSAS GKYVADFSLF DQVVKVASPG GLRDSTVRYG DPEKLKLEES LREQAEKEGS ALSVRISNV. It is sometimes possible for the material contained within the vial of "ATP-sensitive inward rectifier potassium channel 10 (Kcnj10), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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