KChIP3 Blocking Peptide | KCNIP3 blocking peptide
KChIP3 Antibody (N-term M1) Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing.
Protein type: Transcription factor; Calcium-binding
Chromosomal Location of Human Ortholog: 2q21.1
Cellular Component: cytosol; plasma membrane; voltage-gated potassium channel complex
Molecular Function: DNA binding; potassium channel regulator activity; protein binding; transcription corepressor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; signal transduction
Research Articles on KCNIP3
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Product Notes
The KCNIP3 kcnip3 (Catalog #AAA9221346) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KChIP3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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