Voltage-gated potassium channel subunit beta-2 (Kcnab2) Recombinant Protein | Kcnab2 recombinant protein

Recombinant Rat Voltage-gated potassium channel subunit beta-2 (Kcnab2)

Cat. Num. AAA956299

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Voltage-gated potassium channel subunit beta-2 (Kcnab2); Recombinant Rat Voltage-gated potassium channel subunit beta-2 (Kcnab2); Kcnab2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-367, Full length protein
• Sequence: MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS
• Sequence Length: 367

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for Kcnab2 recombinant protein

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 8393646
• NCBI GeneID: 29738
• NCBI Accession #: NP_059000.1
• NCBI GenBank Nucleotide #: NM_017304.2
• UniProt Accession #: P62483; P97381; Q60942; Q64284
• Molecular Weight: 41,021 Da
• NCBI Official Full Name: voltage-gated potassium channel subunit beta-2
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily A regulatory beta subunit 2
• NCBI Official Symbol: Kcnab2
• NCBI Protein Information: voltage-gated potassium channel subunit beta-2
• UniProt Protein Name: Voltage-gated potassium channel subunit beta-2
• Protein Family: Voltage-gated potassium channel
• UniProt Gene Name: Kcnab2
• UniProt Synonym Gene Names: Ckbeta2; Kcnb3

NCBI Description

voltage gated potassium channel beta subunit; modifies the inactivation kinetics of the channel [RGD, Feb 2006]

Uniprot Description

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:9763623, PubMed:21357749). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (PubMed:10896669, PubMed:16770729, PubMed:18003609, PubMed:21357749). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:21357749). Modulates the functional properties of KCNA4 (PubMed:9763623). Modulates the functional properties of KCNA5 (). Enhances KCNB2 channel activity (). Binds NADPH and has NADPH-dependent aldoketoreductase activity (PubMed:18672894, PubMed:21209188). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (PubMed:18672894).