Mouse potassium voltage-gated channel, shaker-related subfamily, member 5 ELISA Kit | KCNA5 elisa kit
Mouse Potassium voltage-gated channel subfamily A member 5, KCNA5 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Kv1.5: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. Defects in KCNA5 are the cause of familial atrial fibrillation type 7 (ATFB7). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass
Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; intracellular canaliculus; membrane; integral to plasma membrane; endoplasmic reticulum; perinuclear region of cytoplasm; integral to membrane; plasma membrane; cytosol; Z disc; lipid raft
Molecular Function: protein binding; voltage-gated potassium channel activity; potassium channel activity; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity; potassium channel inhibitor activity; alpha-actinin binding; protein kinase binding; receptor binding
Biological Process: regulation of potassium ion transport; negative regulation of potassium ion transport; membrane hyperpolarization; protein oligomerization; regulation of membrane potential; transport; reduction of cytosolic calcium ion concentration; regulation of vasoconstriction; ion transport; potassium ion homeostasis; transmembrane transport; potassium ion transport; protein homooligomerization
Research Articles on KCNA5
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Product Notes
The Mouse KCNA5 kcna5 (Catalog #AAA9340452) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340452 ELISA Kit recognizes Mouse KCNA5. It is sometimes possible for the material contained within the vial of "potassium voltage-gated channel, shaker-related subfamily, member 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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