Kappa-conotoxin RIIIJ Recombinant Protein | Kappa-M-RIIIJ recombinant protein
Recombinant Conus radiatus Kappa-conotoxin RIIIJ
NCBI and Uniprot Product Information
Uniprot Description
Function: Kappa-conotoxins inhibits voltage-gated potassium channels. This toxin dose-dependently and reversibly inhibits the Kv1.2/KCNA2 channel in mammalia. Does not exert protective effect on cardiac tissue when administered after an ischemic event. Ref.1
Subcellular location: Secreted.
Tissue specificity: Expressed by the venom duct.
Domain: The cysteine framework is III (CC-C-C-CC). Classified in the M-4 branch, since 4 residues stand between the fourth and the fifth cysteine residues.
Miscellaneous: Has no or very low potency for Kv1.1/KCNA1, Kv1.3/KCNA3, Kv1.4/KCNA4, Kv1.5/KCNA5, Kv1.6/KCNA6, Kv7.2/KCNQ2-Kv7.3/KCNQ3, and KCa1.1/KCNMA1 (Ref.1).
Sequence similarities: Belongs to the conotoxin M superfamily.
Mass spectrometry: Molecular mass is 2805.84 Da from positions 1 - 25. Determined by ESI. monoisotopic mass. Ref.1
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Product Notes
The Kappa-conotoxin RIIIJ kappa-m-riiij (Catalog #AAA1198360) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-25aa; Cytoplasmic domain. The amino acid sequence is listed below: LPPCCTPPKK HCPAPACKYK PCCKS. It is sometimes possible for the material contained within the vial of "Kappa-conotoxin RIIIJ, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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