KN motif and ankyrin repeat domain-containing protein 2 (KANK2) Recombinant Protein | KANK2 recombinant protein

Recombinant Human KN motif and ankyrin repeat domain-containing protein 2 (KANK2) , partial

• Gene Names: KANK2; SIP; MXRA3; PPKWH; NPHS16; ANKRD25
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: KN motif and ankyrin repeat domain-containing protein 2 (KANK2); Recombinant Human KN motif and ankyrin repeat domain-containing protein 2 (KANK2); partial; KANK2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 841

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 209969812
• NCBI GeneID: 25959
• NCBI Accession #: NP_001129663.1
• NCBI GenBank Nucleotide #: NM_001136191.2
• UniProt Accession #: Q63ZY3; Q3KQZ3; Q6GUF5; Q9H8S4; Q9NUP0; Q9P210; B0I1P4
• Molecular Weight: 90,044 Da
• NCBI Official Full Name: KN motif and ankyrin repeat domain-containing protein 2 isoform 2
• NCBI Official Synonym Full Names: KN motif and ankyrin repeat domains 2
• NCBI Official Symbol: KANK2
• NCBI Official Synonym Symbols: SIP; MXRA3; PPKWH; NPHS16; ANKRD25
• NCBI Protein Information: KN motif and ankyrin repeat domain-containing protein 2
• UniProt Protein Name: KN motif and ankyrin repeat domain-containing protein 2
• Protein Family: KN motif and ankyrin repeat domain-containing protein
• UniProt Gene Name: KANK2
• UniProt Synonym Gene Names: ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein; SRC1-interacting protein

NCBI Description

This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]

Uniprot Description

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation ().