Zinc metalloproteinase-disintegrin jararhagin Recombinant Protein | JF I recombinant protein
Recombinant Bothrops jararaca Zinc metalloproteinase-disintegrin jararhagin
NCBI and Uniprot Product Information
Uniprot Description
Snake venom zinc metalloproteinase-disintegrin-like jararhagin: causes hemorrhage. This is the result of the degradation of sub-endothelial matrix proteins leading to the disruption of the blood vessel endothelium, with accompanying disturbances in platelet function. It is able to degrade von Willebrand factor (vWF) and it hydrolyzes the alpha-chain of fibrinogen (FGA) while leaving the beta and gamma chains unaffected. It inhibits collagen-induced platelet aggregation through the binding to alpha-2/beta-1 integrin (ITGA2/ITGB1) (collagen receptor), and it cleaves the beta-1 subunit of the same integrin, inhibiting platelet interaction and ultimately causing impairment of signal transduction. It has inability to be affected by the plasma inhibitor alpha2-macroglobulin. In fibroblasts, it functions as a collagen-mimetic substrate and, in endothelial cells, it causes apoptosis and indirectly inhibits cell proliferation by release of angiostatin-like compounds. It induces a strong pro-inflammatory response characterized by intense leukocyte accumulation and release of cytokines at the site of the injection. Although hemorrhage and edema are a response to the direct effect of this toxin, jararhagin-induced inflammation and necrosis are dependent on macrophages and key pro-inflammatory cytokines or their receptors. It also possesses anti-tumorgenic properties.
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Product Notes
The Zinc metalloproteinase-disintegrin jararhagin jf i (Catalog #AAA1244819) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 151-571, Full length protein. The amino acid sequence is listed below: EQQRYDPYKY IEFFVVVDQG TVTKNNGDLD KIKARMYELA NIVNEIFRYL YMHVALVGLE IWSNGDKITV KPDVDYTLNS FAEWRKTDLL TRKKHDNAQL LTAIDFNGPT IGYAYIGSMC HPKRSVGIVQ DYSPINLVVA VIMAHEMGHN LGIHHDTGSC SCGDYPCIMG PTISNEPSKF FSNCSYIQCW DFIMNHNPEC IINEPLGTDI ISPPVCGNEL LEVGEECDCG TPENCQNECC DAATCKLKSG SQCGHGDCCE QCKFSKSGTE CRASMSECDP AEHCTGQSSE CPADVFHKNG QPCLDNYGYC YNGNCPIMYH QCYALFGADV YEAEDSCFKD NQKGNYYGYC RKENGKKIPC APEDVKCGRL YCKDNSPGQN NPCKMFYSND DEHKGMVLPG TKCADGKVCS NGHCVDVATA Y. It is sometimes possible for the material contained within the vial of "Zinc metalloproteinase-disintegrin jararhagin, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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