Mouse jumonji, AT rich interactive domain 2 ELISA Kit | JARID2 elisa kit
Mouse Protein Jumonji, JARID2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
JARID2: a Polycomb protein required for neural tube formation. Contains a Jumonji C domain but lacks histone demethylase activity. Essential for normal heart development and function. Required for embryonic viability. Down-regulation of Jarid2 impairs ES cell differentiation and Oct4 silencing. Associates with the Polycomb-Repressive Complex 2 (PRC2), stimulating PRC2 methyltransferase activity. PRC2 includes the histone H3 Lys 27 (H3K27) methyltransferase Ezh2, EED, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The recruitment of PRC2 to a promoter leads to increased levels of di- and trimethylation of H3K27 (H3K27me2/3), regulating the balance between self-renewal and differentiation of embryonic stem cells. The ability of Jarid 2 to be recruited to DNA in ES cells is interdependent on PRC2. Its knockdown reduces PRC2 at its target promoters, while ES cells lacking the PRC2 component EED are deficient in Jarid2 promoter activity. Acts as a transcriptional repressor of ANF by binding to both GATA4 and NKX2-5 and repressing their transcriptional activator activities. Participates in the negative regulation of cell proliferation signaling. Interacts with the N-terminal region of GATA4 and the C- terminal region of the NKX2-5 homeobox and represses their ability to activate transcription of ANF.
Protein type: Transcription, coactivator/corepressor
Cellular Component: histone methyltransferase complex; ESC/E(Z) complex; nucleus
Molecular Function: protein binding; histone demethylase activity; DNA binding; chromatin binding
Biological Process: spleen development; transcription from RNA polymerase II promoter; positive regulation of histone H3-K9 methylation; thymus development; transcription, DNA-dependent; multicellular organismal development; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; stem cell differentiation; liver development; negative regulation of histone methylation; regulation of cell proliferation; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; cell differentiation
Research Articles on JARID2
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Product Notes
The Mouse JARID2 jarid2 (Catalog #AAA9339464) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339464 ELISA Kit recognizes Mouse JARID2. It is sometimes possible for the material contained within the vial of "jumonji, AT rich interactive domain 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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