Jagged 2 Protein (JAG2) Recombinant Protein | JAG2 recombinant protein

Recombinant Jagged 2 Protein (JAG2)

Cat. Num. AAA2010725

• Gene Names: Jag2; sm; Serh; D12Ggc2e; mJagged2-1
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Jagged 2 Protein (JAG2); Recombinant Jagged 2 Protein (JAG2); JAG2 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.; MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-CH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCTIA KNSSCVPNPC VNGGTCVGSG DSFSCICRDG WEGRTCTHNT NDCNPLPCYN GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR CSCPPGRSGP RCQEVVIFTR PCWSRGMSFP HGSSWMEDCN SCRCLDGHRD CSKVWCGWKP CLLSGQPSDP SAQCPPGQQC QEKAVGQCLQ P
• Sequence Length: 1247

• Applicable Applications for JAG2 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Mus musculus (Mouse)
• Expression System: Prokaryotic expression
• Residues: Cys709~Pro941 (Accession # Q9QYE5) with two N-terminal Tags, His-tag and T7-tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 146134329
• NCBI GeneID: 16450
• NCBI Accession #: NP_034718.2
• NCBI GenBank Nucleotide #: NM_010588.2
• UniProt Accession #: Q9QYE5; O55139; O70219; F8VPV5
• Molecular Weight: 28.9kDa
• NCBI Official Full Name: protein jagged-2
• NCBI Official Synonym Full Names: jagged 2
• NCBI Official Symbol: Jag2
• NCBI Official Synonym Symbols: sm; Serh; D12Ggc2e; mJagged2-1
• NCBI Protein Information: protein jagged-2; syndactylism
• UniProt Protein Name: Protein jagged-2
• Protein Family: Protein jagged
• UniProt Gene Name: Jag2
• UniProt Synonym Gene Names: Jagged2
• UniProt Entry Name: JAG2_MOUSE

Uniprot Description

JAG2: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: membrane; perinuclear region of cytoplasm; integral to plasma membrane; integral to membrane

Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding

Biological Process: regulation of cell adhesion; thymic T cell selection; Notch signaling pathway; in utero embryonic development; multicellular organismal development; cell fate determination; regulation of cell proliferation; odontogenesis of dentine-containing teeth; respiratory system process; sensory perception of sound; morphogenesis of embryonic epithelium; spermatogenesis; cell communication; cell differentiation; auditory receptor cell fate commitment; skeletal development; T cell differentiation; gamma-delta T cell differentiation