NCBI and Uniprot Product Information
NCBI Description
ligand responsible for activating Notch1 [RGD, Feb 2006]
Uniprot Description
JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Protein type: Membrane protein, integral
Cellular Component: adherens junction; apical part of cell; apical plasma membrane; plasma membrane
Molecular Function: Notch binding; protein binding
Biological Process: auditory receptor cell differentiation; blood vessel remodeling; camera-type eye development; inner ear development; morphogenesis of an epithelial sheet; negative regulation of cell differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; Notch signaling pathway; organ morphogenesis; organ regeneration; positive regulation of myeloid cell differentiation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; response to muramyl dipeptide; T cell mediated immunity
Research Articles on Jag1
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Product Notes
The Rat Jag1 jag1 (Catalog #AAA2887415) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2887415 ELISA Kit recognizes Rat Jag1. It is sometimes possible for the material contained within the vial of "Protein jagged-1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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