Omentin/Intelectin-1/ITLN-1 Recombinant Protein | ITLN-1 recombinant protein

Recombinant Human Omentin/Intelectin-1/ITLN-1 Protein (N-6His)

Cat. Num. AAA2553032

• Gene Names: ITLN1; HL1; LFR; HL-1; INTL; ITLN; hIntL; omentin
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: Omentin/Intelectin-1/ITLN-1; Recombinant Human Omentin/Intelectin-1/ITLN-1 Protein (N-6His); Intelectin-1; ITLN-1; Endothelial lectin HL-1; Galactofuranose-binding lectin; Intestinal lactoferrin receptor; Omentin; INTL; ITLN; LFR; ITLN-1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 50mM Tris, 100mM NaCl, 5mM GSH, 0.5mM GSSG, pH 8.0.
• Sequence Positions: Thr19-Ser298
• Sequence Length: 313

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for ITLN-1 recombinant protein

Intelectin-1(ITLN1) is a secreted protein and contains 1 fibrinogen C-terminal domain. Intelectin-1 is a 40 kDa Ca-dependent galactofuranose-binding lectin that is not a C-type lectin. It is expressed on multiple cell types and appears to participate in insulin signaling and microbe recognition. The protein has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. It increases AKT phosphorylation in the absence and presence of insulin and it may play a role in the defense systemagainst microorganisms. It also may specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosy l residues, in a calcium-dependent manner.

NCBI and Uniprot Product Information

• NCBI GI #: 31542986
• NCBI GeneID: 55600
• NCBI Accession #: NP_060095.2
• NCBI GenBank Nucleotide #: NM_017625.2
• UniProt Accession #: Q8WWA0; Q5IWS4; Q5VYI4; Q6YDJ3; Q9NP67
• Molecular Weight: Molecular Mass: 32.7 kDa; Actual Protein Molecular Mass: 35 kDa
• NCBI Official Full Name: intelectin-1
• NCBI Official Synonym Full Names: intelectin 1
• NCBI Official Symbol: ITLN1
• NCBI Official Synonym Symbols: HL1; LFR; HL-1; INTL; ITLN; hIntL; omentin
• NCBI Protein Information: intelectin-1
• UniProt Protein Name: Intelectin-1
• UniProt Gene Name: ITLN1
• UniProt Synonym Gene Names: INTL; ITLN; LFR; ITLN-1

Uniprot Description

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).