ITIH3 recombinant protein

ITIH3 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8122056

• Gene Names: ITIH3; H3P; SHAP; ITI-HC3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: ITIH3; ITIH3 Protein; Human; Recombinant (His Tag); Human ITIH3 Protein (His Tag); H3P Protein; ITI-HC3 Protein; SHAP Protein; inter-alpha-trypsin inhibitor heavy chain 3; ITIH3 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asp651

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gly 21
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human ITIH3 (NP_002208.3)(Met1-Asp651) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for ITIH3 recombinant protein

Background: ITIH3 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 3) is a Protein Coding gene. This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. ITIH3 is involved in the stabilization of the extracellular matrix. A polymorphism (rs2535629) of ITIH3 showed the strongest association signal with susceptibility to psychiatric disorders in Caucasian populations. Common single nucleotide polymorphisms (SNPs) in or near the inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) gene have been repeatedly associated with schizophrenia and related psychiatric disorders in genome-wide association studies.ITIH3 may be a useful biomarker for the early detection of gastric cancer. Diseases associated with ITIH3 include Schizophrenia and Major Depressive Disorder.

NCBI and Uniprot Product Information

• NCBI GI #: 133925809
• NCBI GeneID: 3699
• NCBI Accession #: NP_002208.3
• NCBI GenBank Nucleotide #: NM_002217.3
• UniProt Accession #: Q06033; Q3B7H5; Q53F06; Q6LAM2; Q99085
• Molecular Weight: 99,328 Da
• NCBI Official Full Name: inter-alpha-trypsin inhibitor heavy chain H3 preproprotein
• NCBI Official Synonym Full Names: inter-alpha-trypsin inhibitor heavy chain 3
• NCBI Official Symbol: ITIH3
• NCBI Official Synonym Symbols: H3P; SHAP; ITI-HC3
• NCBI Protein Information: inter-alpha-trypsin inhibitor heavy chain H3
• UniProt Protein Name: Inter-alpha-trypsin inhibitor heavy chain H3
• Protein Family: Inter-alpha-trypsin inhibitor
• UniProt Gene Name: ITIH3
• UniProt Synonym Gene Names: ITI heavy chain H3; ITI-HC3; Inter-alpha-inhibitor heavy chain 3; SHAP

NCBI Description

This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015]

Uniprot Description

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.