Integrin alpha-7 (ITGA7) Recombinant Protein | ITGA7 recombinant protein

Recombinant Human Integrin alpha-7 (ITGA7) , partial

Cat. Num. AAA1328883

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Integrin alpha-7 (ITGA7); Recombinant Human Integrin alpha-7 (ITGA7); partial; ITGA7 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 959-1181aa; Partial
• Sequence: ELEPPEQQEPGERQEPSMSWWPVSSAEKKKNITLDCARGTANCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYSAVKSLEVIVRANITVKSSIKNLMLRDASTVIPVMVYLDPMAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDAHPILAADGHPELGPDGHPGPGTA

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for ITGA7 recombinant protein

This protein belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 222418613
• NCBI GeneID: 3679
• NCBI Accession #: NP_001138468.1
• NCBI GenBank Nucleotide #: NM_001144996.1
• UniProt Accession #: Q13683; O43197; Q86W93; Q9NY89; Q9UET0; Q9UEV2; B4E3U0; C9JMD3; C9JMZ6
• Molecular Weight: 114,545 Da
• NCBI Official Full Name: integrin alpha-7 isoform 1
• NCBI Official Synonym Full Names: integrin subunit alpha 7
• NCBI Official Symbol: ITGA7
• NCBI Protein Information: integrin alpha-7
• UniProt Protein Name: Integrin alpha-7
• Protein Family: Integrin
• UniProt Gene Name: ITGA7

NCBI Description

The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]

Uniprot Description

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.