Integrin-alpha FG-GAP repeat-containing protein 2 (ITFG2) Recombinant Protein | ITFG2 recombinant protein

Recombinant Human Integrin-alpha FG-GAP repeat-containing protein 2 (ITFG2)

Cat. Num. AAA1356215

• Gene Names: ITFG2; FGGAP1; MDS028
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Integrin-alpha FG-GAP repeat-containing protein 2 (ITFG2); Recombinant Human Integrin-alpha FG-GAP repeat-containing protein 2 (ITFG2); ITFG2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-447, Full length protein
• Sequence: MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKVSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLLVAVSAEGWFHLFDLTPAKVLDASGHHETLIGEEQRPVFKQHIPANTKVMLISDIDGDGCRELVVGYTDRVVRAFRWEELGEGPEHLTGQLVSLKKWMLEGQVDSLSVTLGPLGLPELMVSQPGCAYAILLCTWKKDTGSPPASEGPTDGSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIKQGHGTESSGSGLFALCTLDGTLKLMEEMEEADKLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLVKLLETKPEYHSLLQELGVDPDDLPVTRALLHQTLYHPDQPPQCAPSSLQDPT
• Sequence Length: 447

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 271397437
• NCBI GeneID: 55846
• NCBI Accession #: NP_060933.3
• NCBI GenBank Nucleotide #: NM_018463.3
• UniProt Accession #: Q969R8; Q6PKU5; Q96SX6; A8K4Z5; D3DUQ2
• Molecular Weight: 15,974 Da
• NCBI Official Full Name: KICSTOR complex protein ITFG2
• NCBI Official Synonym Full Names: integrin alpha FG-GAP repeat containing 2
• NCBI Official Symbol: ITFG2
• NCBI Official Synonym Symbols: FGGAP1; MDS028
• NCBI Protein Information: KICSTOR complex protein ITFG2; integrin-alpha FG-GAP repeat-containing protein 2
• UniProt Protein Name: KICSTOR complex protein ITFG2
• Protein Family: Integrin-alpha FG-GAP repeat-containing protein
• UniProt Gene Name: ITFG2

Uniprot Description

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.