TGF-beta2 active protein
Human TGF-beta2
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Uniprot Description
Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
Subunit structure: Homodimer; disulfide-linked
By similarity. Heterodimers with TGFB1 and with TGFB3 have been found in bone
By similarity. Interacts with the serine proteases, HTRA1 and HTRA3
By similarity. Latency-associated peptide interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction
By similarity. Interacts with ASPN. Ref.11
Subcellular location: Secreted.
Post-translational modification: The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive
By similarity.
Involvement in disease: A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.Loeys-Dietz syndrome 4 (LDS4) [MIM:614816]: An aortic aneurysm syndrome with widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on TGF-beta2
Similar Products
Product Notes
The TGF-beta2 tgfb2 (Catalog #AAA691654) is an Active Protein produced from Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The Human TGF-beta2 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAG ACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY Y IGKTPKIEQ LSNMIVKSCK CS. It is sometimes possible for the material contained within the vial of "TGF-beta2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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