Activin-B active protein
Human Activin-B
NCBI and Uniprot Product Information
NCBI Description
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Recognizes the double-stranded sequence GGCC and cleaves after G-2.
Catalytic activity: Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
Cofactor: Magnesium.
Subunit structure: Monomer.
Research Articles on Activin-B
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Product Notes
The Activin-B hsdrr (Catalog #AAA692002) is an Active Protein produced from Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The Human Activin-B reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GLECDGRTNL CCRQQFFIDF RLIGWNDWII APTGYYGNYC EGSCPA YLAG VPGSASSFHT AVVNQYRMRG LNPGTVNSCC IPTKLSTMSM L YFDDEYNIV KRDVPNMIVE ECGCA. It is sometimes possible for the material contained within the vial of "Activin-B, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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