Structure
Zosuquidar trihydrochloride, Inhibitor
Zosuquidar trihydrochloride
Purity
>98% (HPLC)
Synonyms
Zosuquidar trihydrochloride; LY-335979 trihydrochloride; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
P-glycoprotein
Receptor
P-gp (P-glycoprotein)
Chemical Name
1-Piperazineethanol, 4-[(1a.alpha., 6.alpha., 10b.alpha.)-1, 1-difluoro-1, 1a, 6, 10b-tetrahydrodibenzo[a, e]cyclopropa[c]cyclohepten-6-yl]-.alpha.-[(5-quinolinyloxy)methyl]-, hydrochloride(1:3), (.alpha.R)
SMILES
FC1([C@H]2[C@@H]1C3=C([C@@H](C4=CC=CC=C42)N5CCN(CC5)C[C@H](COC6=C7C=CC=NC7=CC=C6)O)C=CC=C3)F.Cl.Cl.Cl
Molecular Formula
C32H34Cl3F2N3O2
CAS Number
167465-36-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Zosuquidar trihydrochloride, inhibitor
A potent P-glycoprotein (P-gp) inhibitor with Ki of 60nM; fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1uM; enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model. Blood Cancer Phase 3 Discontinued
Product Categories/Family for Zosuquidar trihydrochloride, inhibitor
References
1. Slate DL, et al. Anticancer Res. 1995 May-Jun; 15 (3):811-4.
2. Dantzig AH, et al. Cancer Res. 1996 Sep 15; 56 (18):4171-9.
3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug; 290 (2):854-62.
2. Dantzig AH, et al. Cancer Res. 1996 Sep 15; 56 (18):4171-9.
3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug; 290 (2):854-62.
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Product Notes
The Zosuquidar trihydrochloride (Catalog #AAA3602557) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Zosuquidar trihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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