Testing Data
(Jurkat cells were treated with W6000-06 at varying concentrations and assayed using Akt (Total) and [pS473] phosphoELISA. Data show effective inhibition of Akt phosphorylation using the wortmannin inhibitor.)
Wortmannin, Penicillium fumiculosum, Inhibitor
Wortmannin, Penicillium fumiculosum (PI 3-Kinase Inhibitor, KY 12420)
Purity
~98%, as assessed by TLC
Synonyms
Wortmannin; Penicillium fumiculosum; Penicillium fumiculosum (PI 3-Kinase Inhibitor; KY 12420); inhibitor
Purity/Purification
~98%, as assessed by TLC
Form/Format
Supplied as a white, lyophilized powder.
CAS Number
19545-26-7
Molecular Formula
C23H24O8
Solubility
Soluble in DMSO or ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with DMSO or ethanol. Make solutions fresh, immediately before use. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Testing Data
(Jurkat cells were treated with W6000-06 at varying concentrations and assayed using Akt (Total) and [pS473] phosphoELISA. Data show effective inhibition of Akt phosphorylation using the wortmannin inhibitor.)
Testing Data
(Jurkat cells were treated with W6000-06 at varying concentrations and assayed using Akt (Total) and [pS473] phosphoELISA. Data show effective inhibition of Akt phosphorylation using the wortmannin inhibitor.)
Related Product Information for Wortmannin, Penicillium fumiculosum, inhibitor
Wortmannin, a fungal metabolite, is a potent and selective inhibitor of phosphatidylinositol 3-kinase. This compound is active with purified preparations and cytosolic fractions and because it is highly cell-permeable, it is also suitable for use with intact cells. Several biological effects are observed with wortmannin treatment, including the inhibition of fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils and the blockage of the metabolic effects of insulin in isolated rat adipocytes without effect on the insulin receptor tyrosine kinase activity. The mechanism of wortmannin's inhibition of PI 3-kinase has been determined to be the formation of a covalent bond with its target. Wortmannin's inhibition of PI 3-kinase is selective and inhibition of other kinases such as PI 4-kinase and myosin light chain kinase, occurs at concentrations 100 fold higher than those required for inhibition of PI 3-kinase.
Product Categories/Family for Wortmannin, Penicillium fumiculosum, inhibitor
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Product Notes
The Wortmannin, Penicillium fumiculosum (Catalog #AAA655343) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Wortmannin, Penicillium fumiculosum, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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