Structure

Vardenafil hydrochloride, Inhibitor

Vardenafil hydrochloride

Purity

99.76%

Synonyms

Vardenafil hydrochloride; inhibitor

Ordering
Cat. Num. AAA5759208 For Research Use Only!

Purity/Purification

99.76%

Form/Format

Solid. Powder

Solubility

DMSO: 100mg/mL (190.45mM) Need ultrasonic
H2O: 100mg/mL (190.45mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H33ClN6O4S

SMILES

Cl.CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1

CAS Number

224785-91-5

Target & IC50

PDE5

In Vitro

After 12 weeks of treatment, a dose-dependent (P = 0.02) improvement in erections was noted for the GAQ, with 57 and 72% of men taking 10mg or 20mg vardenafil, respectively, reporting improved erections, in contrast to 13% after taking placebo (P <0.0001). For the erectile function domain, dose-dependent (P = 0.03) final scores for the 10- and 20-mg dose were 17.1 and 19.0 compared with 12.6 for placebo (P <0.0001). Both vardenafil doses significantly enhanced the rates of successful penetration (P <0.0001) and successful intercourse (P <0.0001) compared with placebo. Vardenafil treatment,was effective in increasing intercourse success rates at all levels of baseline ED severity, at each level of plasma HbA(1c), and for type 1 and 2 diabetes. Treatment, emergent adverse events were primarily mild to moderate headache (

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Related Product Information for Vardenafil hydrochloride, inhibitor

Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the treatment,of Erectile Dysfunction in Men With Diabetes

Product Categories/Family for Vardenafil hydrochloride, inhibitor

Metabolism; PDE

References

Irwin Goldstein, Jay M Young, Jerome Fischer.Vardenafil, a New Phosphodiesterase Type 5 Inhibitor, in the treatment,of Erectile Dysfunction in Men With Diabetes: A Multicenter Double-Blind Placebo-Controlled Fixed-Dose Study.Diabetes Care. 2003 Mar;26(3):777-83.
Irwin Goldstein, Jay M Young, Jerome Fischer.Vardenafil, a New Phosphodiesterase Type 5 Inhibitor, in the treatment,of Erectile Dysfunction in Men With Diabetes: A Multicenter Double-Blind Placebo-Controlled Fixed-Dose Study.Diabetes Care. 2003 Mar;26(3):777-83.
Saenz de Tejada, I., et al., The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res, 2001. 13(5): p. 282-90.
Saenz de Tejada, I., et al., The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res, 2001. 13(5): p. 282-90.

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Product Notes

The Vardenafil hydrochloride (Catalog #AAA5759208) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Vardenafil hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Vardenafil hydrochloride, Inhibitor