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Testing Data

Trichostatin A (TSA), Inhibitor | TSA, inhibitor

Trichostatin A (TSA)

Gene Names
PRDX2; PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a
Purity
0.98
Synonyms
Trichostatin A (TSA); TSA; inhibitor
Ordering
For Research Use Only!
Purity/Purification
0.98
Sequence Length
164
Solubility
DMSO >=61mg/mL - Water <1mg/mL - Ethanol <1mg/mL
Formula
C17H22N2O3
CAS Number
58880-19-6
Preparation and Storage
Store at-20 degree C 2 years.

Testing Data

Testing Data
Related Product Information for TSA, inhibitor
An antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture. TSA inhibited proliferation of eight breast carcinoma cell lines with mean +/-SD IC50 of 124.4 +/-120.4 nm (range, 26.4-308.1 nm). HDAC inhibitory activity of TSA was similar in all cell lines with mean +/-SD IC50 of 2.4 +/-0.5 nm (range, 1.5-2.9 nm), and TSA treatment resulted in pronouncing histone H4 hyperacetylation. [1]

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
302.4
NCBI Official Full Name
TSA, partial
NCBI Official Synonym Full Names
peroxiredoxin 2
NCBI Official Symbol
PRDX2
NCBI Official Synonym Symbols
PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a
NCBI Protein Information
peroxiredoxin-2
UniProt Protein Name
Peroxiredoxin-2
UniProt Gene Name
PRDX2
UniProt Synonym Gene Names
NKEFB; TDPX1; NKEF-B; TSA

NCBI Description

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

Uniprot Description

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.

Research Articles on TSA

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Product Notes

The TSA prdx2 (Catalog #AAA8506609) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Trichostatin A (TSA), Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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