Tolcapone, Inhibitor
Tolcapone
Purity
>98%
Synonyms
Tolcapone; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Bio-Activity
COMT inhibitor; TTR aggregation inhibitor
Solubility
Soluble in DMSO (up to 25mg/ml) or in Ethanol (up to 25mg/ml)
Chemical Name
(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
CAS #
134308-13-7
Molecular Formula
C14H11NO5
Preparation and Storage
Store at -20 degree C
Related Product Information for Tolcapone, inhibitor
Tolcapone has demonstrated to be a Catechol O-methyltransferase inhibitor (COMT), limiting brain and peripheral enzymes (1). It is a potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity (2). Tolcapone interacts with transthyretin (TTR) with high affinity (21 to 58 nM) and prevents TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. It also steadies TTR in mice and humans in vivo (3). Tolcapone inhibits O-methylation of exogenous polyphenols such as EGCG (4).
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Product Notes
The Tolcapone (Catalog #AAA556538) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tolcapone, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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