Chemical Structure
Talniflumate, Inhibitor
Talniflumate
Purity
98.00%
Synonyms
Talniflumate; chloride channel blocker; COX inhibitor; Anion exchanger inhibitor; N-acetylglucosaminyltransferase inhibitor; inhibitor
Purity/Purification
98.00%
Form/Format
POWDER
CAS Number
66898-62-2
Formula
C21H13F3N2O4
Smiles
FC(F)(F)c1cccc(Nc2ncccc2C(=O)OC2OC(=O)c3ccccc23)c1
Solubility
DMSO: 10 mg/mL
Pathways
Membrane Transporter; Ion Channel; Immunology; Inflammation; Metabolism
Receptor
hCLCA1/mCLCA3; COX; Cl-/HCO3- exchanger; GCNT3
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
In Solvent: 2 years -80 degree C
Chemical Structure
Chemical Structure
Related Product Information for Talniflumate, inhibitor
Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.
References
1. Knight D. Talniflumate (Genaera)[J]. Current Opinion in Investigational Drugs, 2004, 5(5):557-62.
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Product Notes
The Talniflumate (Catalog #AAA5750603) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Talniflumate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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