Chemical Structure
TAE684, Inhibitor
TAE684
Purity
>98%
Synonyms
TAE684; NVP-TAE684; TAE-684; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 16.28 mL (1 mg); 81.41 mL (5 mg); 162.81mL (10 mg)
0.5 mM: 3.26 mL (1 mg); 16.28 mL (5 mg); 32.56 mL (10 mg)
1 mM: 1.63 mL (1 mg); 8.14 mL (5 mg); 16.28 mL (10 mg)
5 mM: 0.33 mL (1 mg); 1.63 mL (5 mg); 3.26 mL (10 mg) (varies by lot)
0.5 mM: 3.26 mL (1 mg); 16.28 mL (5 mg); 32.56 mL (10 mg)
1 mM: 1.63 mL (1 mg); 8.14 mL (5 mg); 16.28 mL (10 mg)
5 mM: 0.33 mL (1 mg); 1.63 mL (5 mg); 3.26 mL (10 mg) (varies by lot)
CAS Number
761439-42-3
Formula
C30H40ClN7O3S
SMILES
CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
Actions
Inhibitor
In Vivo Solvent
30% PEG400/0.5% Tween80/5% propylene glycol, pH 4
Solubility (DMSO)
3 mg/mL (4.88 mM)
Solubility (Ethanol)
<1 mg/mL (<1 mM)
Solubility (in vivo)
10 mg/mL
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder
Chemical Structure
Chemical Structure
Related Product Information for TAE684, inhibitor
TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).
References
Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
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Product Notes
The TAE684 (Catalog #AAA385849) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TAE684, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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