Chemical Structure
PF 573228, Inhibitor
PF 573228
Purity
>98%
Synonyms
PF 573228; PF-573228; PF573228; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 20.35 mL (1 mg); 101.73 mL (5 mg); 203.46mL (10 mg)
0.5 mM: 4.07 mL (1 mg); 20.35 mL (5 mg); 40.69 mL (10 mg)
1 mM: 2.03 mL (1 mg); 10.17 mL (5 mg); 20.35 mL (10 mg)
5 mM: 0.41 mL (1 mg); 2.03 mL (5 mg); 4.07 mL (10 mg) (varies by lot)
0.5 mM: 4.07 mL (1 mg); 20.35 mL (5 mg); 40.69 mL (10 mg)
1 mM: 2.03 mL (1 mg); 10.17 mL (5 mg); 20.35 mL (10 mg)
5 mM: 0.41 mL (1 mg); 2.03 mL (5 mg); 4.07 mL (10 mg) (varies by lot)
CAS Number
869288-64-2
Formula
C22H20F3N5O3S
SMILES
CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4
Actions
Inhibitor
In Vivo Solvent
30% PEG400/0.5% Tween80/5% propylene glycol
Solubility (DMSO)
26 mg/mL (52.9 mM)
Solubility (Ethanol)
<1 mg/mL (<1 mM)
Solubility (in vivo)
30 mg/mL
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder
Chemical Structure
Chemical Structure
Related Product Information for PF 573228, inhibitor
PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM).
References
Izumi D, .et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer, Int J Cancer, 2016, Mar 1;138(5):1207-19 PMID: 26414794
Aya Yokota-Nakatsuma, .et al. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties, Sci Rep, 2016, 6: 37914 PMID: 27897208
Aya Yokota-Nakatsuma, .et al. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties, Sci Rep, 2016, 6: 37914 PMID: 27897208
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Product Notes
The PF 573228 (Catalog #AAA385930) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PF 573228, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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