Chemical Structure
Sephin1, Inhibitor
Sephin1
Purity
0.998
Synonyms
Sephin1; IFB-088; NSC 65390; inhibitor
Purity/Purification
0.998
Form/Format
Solid
Solubility
H2O: insoluble
DMSO: 7mg/ml(35.60mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
DMSO: 7mg/ml(35.60mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
NC(N)=NN=Cc(cccc1)c1Cl
Formula
C8H9ClN4
In vitro
Sephin1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases in mice, Charcot-Marie-Tooth 1B, and amyotrophic lateral sclerosis[2].
CAS Number
13098-73-2
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for Sephin1, inhibitor
Sephin1 is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2alpha
Product Categories/Family for Sephin1, inhibitor
References
Ruiz A, Zuazo J, Ortiz-Sanz C, et al. Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response[J]. International Journal of Molecular Sciences, 2020, 21(17):6088.
Das I, Krzyzosiak A, Schneider K, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit[J]. Science, 2015, 348(6231):239-242.
Das I, Krzyzosiak A, Schneider K, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit[J]. Science, 2015, 348(6231):239-242.
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Product Notes
The Sephin1 (Catalog #AAA5764816) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Sephin1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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