Semapimod, Inhibitor

Semapimod

• Purity: >98% (HPLC)
• Synonyms: Semapimod; CNI 1493; AXD-455; inhibitor

• Purity/Purification: >98% (HPLC)

• Target: TLR
• Receptor: TLR
• Chemical Name: N1, N10-bis(3-(1-(2-carbamimidoylhydrazono)ethyl)-5-(1-(2-carbamimidoylhydrazono)ethyl)phenyl)decanediamide
• SMILES: CC(=NN=C(N)N)C1=CC(=CC(=C1)NC(=O)CCCCCCCCC(=O)NC2=CC(=CC(=C2)C(=NN=C(N)N)C)C(=NN=C(N)N)C)C(=NN=C(N)N)C
• Molecular Formula: C34H52N18O2
• CAS Number: 352513-83-8
• Preparation and Storage: Store at -20 degree C; Stability: >=2 years; Shipping: Ice Pack

Structure

Related Product Information for Semapimod, inhibitor

Semapimod (CNI 1493; AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3uM) by targeting the TLR chaperone gp96; does not inhibit EDRF activity, inhibits nitric oxide synthesis by inflammatory macrophages; prevents the development of carrageenan-induced footpad inflammation, and conferred protection against lethal LPS challenge in mice. Irritable Bowel Syndrome Phase 2 Clinical

Product Categories/Family for Semapimod, inhibitor

Irritable Bowel Syndrome; Immunology/Inflammation; Other Indications

References

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2. Bianchi M, et al. J Exp Med. 1996 Mar 1; 183 (3):927-36.
3. Wang J, et al. J Immunol. 2016 Jun 15; 196 (12):5130-7.
4. Dotan I, et al. Gut. 2010 Jun; 59 (6):760-6.