Structure
Linaclotide Biochemical
Linaclotide
Purity
>98% (HPLC)
Synonyms
Linaclotide; Linaclotide biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Guanylate Cyclase
Receptor
Guanylate Cyclase
Chemical Name
L-Tyrosine, L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic(1-->6), (2-->10), (5-->13)-tris(disulfide)
SMILES
CC1C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)CNC(=O)C(NC2=O)C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)O)C(=O)NC(CSSCC(C(=O)N3)N)C(=O)NC(C(=O)N5CCCC5C(=O)N1)CC(=O)N)CC6=CC=C(C=C6)O)CCC(=O)O
Molecular Formula
C59H79N15O21S6
CAS Number
851199-59-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Linaclotide biochemical
A potent and selective GC-C agonist (Ki=1.23-1.64nM) that elicits pharmacological effects locally in the gastrointestinal tract; induces a significant increase in fluid secretion, accompanied by a significant increase in intraluminal cGMP levels; has potential for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. Irritable Bowel Syndrome Approved
Product Categories/Family for Linaclotide biochemical
References
1. Bryant AP, et al. Life Sci. 2010 May 8; 86 (19-20):760-5.
2. Eutamene H, et al. Neurogastroenterol Motil. 2010 Mar; 22 (3):312-e84.
3. Busby RW, et al. Eur J Pharmacol. 2010 Dec 15; 649 (1-3):328-35.
2. Eutamene H, et al. Neurogastroenterol Motil. 2010 Mar; 22 (3):312-e84.
3. Busby RW, et al. Eur J Pharmacol. 2010 Dec 15; 649 (1-3):328-35.
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Product Notes
The Linaclotide (Catalog #AAA3606180) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Linaclotide, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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