SB 203580, Inhibitor

SB 203580

Cat. Num. AAA386109

• Purity: >98%
• Synonyms: SB 203580; SB-203580; SB203580; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 26.5 mL (1 mg); 132.49 mL (5 mg); 264.97mL (10 mg); 0.5 mM: 5.3 mL (1 mg); 26.5 mL (5 mg); 52.99 mL (10 mg); 1 mM: 2.65 mL (1 mg); 13.25 mL (5 mg); 26.5 mL (10 mg); 5 mM: 0.53 mL (1 mg); 2.65 mL (5 mg); 5.3 mL (10 mg) (varies by lot)

• CAS Number: 152121-47-6
• Formula: C21H16FN3OS
• SMILES: CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
• Actions: Inhibitor
• Solubility (DMSO): 43 mg/mL (113.92 mM)
• Solubility (Ethanol): <1 mg/mL (<1 mM)
• Solubility (Water): <1 mg/mL (<1 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for SB 203580, inhibitor

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.

References

Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
Uwada J, .et al. Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK, Cell Signal, 2017, Jul;35:188-196 PMID: 28412413
ZHIQIANG ZHANG, .et al. Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway., Mol Med Rep. , 2015, Jul;12(1):1499-505. PMID: 25815691
Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007