Structure
RG7800, inhibitor
RG7800
Purity
98.00%
Synonyms
RG7800; RO6885247; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
Ethanol: 2.5mg/mL (6.00mM) Need ultrasonic
DMSO: 1.4mg/mL (3.36mM) Need ultrasonic and warming
H2O: 1.25mg/mL (3.00mM) ultrasonic and adjust pH to 3 with HCl
(<1mg/ml refers to the product slightly soluble or insoluble)
DMSO: 1.4mg/mL (3.36mM) Need ultrasonic and warming
H2O: 1.25mg/mL (3.00mM) ultrasonic and adjust pH to 3 with HCl
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H28N6O
SMILES
O=C1C=C(C2=NN3C(C(CC)=NC(C)=C3)=C2)N=C4N1C=C(C5CCN(C)CC5)C=C4C
CAS Number
1449598-06-4
Target & IC50
Others
In Vitro
RG7800 is shown to promote the inclusion of exon 7 in SMN2 mRNA, generating full-length mRNA in vitro using fibroblasts from an SMA type I patient. RG7800 increases the SMN protein level via induction of alternative splicing of the SMN2 mRNA [1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for RG7800, inhibitor
RG7800 has the potential for spinal muscular atrophy treatment, RG7800 is an SMN2 splicing modifier.
References
Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100.
Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100.
Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100.
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Product Notes
The RG7800 (Catalog #AAA5753817) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RG7800, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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