Structure
Q203, Inhibitor
Q203
Purity
>98% (HPLC)
Synonyms
Q203; Q-203; Q 203; IAP6; Telacebec; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 10mM
Target
Antibacterial
Receptor
MycobacteriumtuberculosisH37Rv
Chemical Name
Imidazo[1, 2-a]pyridine-3-carboxamide, 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidinyl]phenyl]methyl]
SMILES
CCC1=C(N2C=C(C=CC2=N1)Cl)C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F
Molecular Formula
C29H28ClF3N4O2
CAS Number
1334719-95-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Q203, inhibitor
A novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7nM; does not inhibit any of thecytochrome P450 (CYP450) isoenzymes; targets the respiratory cytochrome bc1 complex and triggers a rapid ATP depletion in M. tuberculosis, also inhibits the growth of MDR and XDR M. tuberculosis; deonstrates potency in mouse model of tuberculosis and displays pharmacokinetic and safety profiles. Bacterial Infection Phase 1 Clinical
Product Categories/Family for Q203, inhibitor
References
1. Pethe K, et al. Nat Med. 2013 Sep; 19 (9):1157-60.
2. Kang S, et al. J Med Chem. 2014 Jun 26; 57 (12):5293-305.
3. Jang J, et al. Antimicrob Agents Chemother. 2017 Jun 27; 61 (7). pii: e02637-16.
2. Kang S, et al. J Med Chem. 2014 Jun 26; 57 (12):5293-305.
3. Jang J, et al. Antimicrob Agents Chemother. 2017 Jun 27; 61 (7). pii: e02637-16.
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Product Notes
The Q203 (Catalog #AAA3601336) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Q203, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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