Structure
Macozinone Biochemical
Macozinone
Purity
>98% (HPLC)
Synonyms
Macozinone; PBTZ169; PBTZ-169; Macozinone biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 6.4mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Antibacterial
Receptor
DprE1
Chemical Name
2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1, 3-benzothiazin-4-one
SMILES
O=C1N=C(N2CCN(CC3CCCCC3)CC2)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14
Molecular Formula
C20H23F3N4O3S
CAS Number
1377239-83-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Macozinone biochemical
Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro; PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043. Bacterial Infection Phase 2 Clinical
Product Categories/Family for Macozinone biochemical
References
1. Makarov V, et al. EMBO Mol Med. 2014 Mar; 6 (3):372-83.
2. Makarov V, et al. Antimicrob Agents Chemother. 2015 Aug; 59 (8):4446-52.
3. Gonzalez-Martinez NA, et al. PLoS Negl Trop Dis. 2015 Oct 16; 9 (10):e0004022.
4. Lechartier B, et al. Antimicrob Agents Chemother. 2015 Aug; 59 (8):4457-63.
2. Makarov V, et al. Antimicrob Agents Chemother. 2015 Aug; 59 (8):4446-52.
3. Gonzalez-Martinez NA, et al. PLoS Negl Trop Dis. 2015 Oct 16; 9 (10):e0004022.
4. Lechartier B, et al. Antimicrob Agents Chemother. 2015 Aug; 59 (8):4457-63.
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Product Notes
The Macozinone (Catalog #AAA3601559) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Macozinone, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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