Phyllanthin, Inhibitor
Phyllanthin
Purity
98.00%
Synonyms
Phyllanthin; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C24H34O6
SMILES
COC[C@@H](Cc(cc1)cc(OC)c1OC)[C@H](Cc(cc1)cc(OC)c1OC)COC
CAS Number
10351-88-9
Target & IC50
NF-kappaB
In Vitro
The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. HypoPhyllanthin and Phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1]
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Phyllanthin, inhibitor
Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
References
Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells.J Pharm Pharmacol. 2013 Feb;65(2):292-9.
Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells.J Pharm Pharmacol. 2013 Feb;65(2):292-9.
Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line.Chem Biol Interact. 2009 Oct 30;181(3):351-8.
Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells.J Pharm Pharmacol. 2013 Feb;65(2):292-9.
Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line.Chem Biol Interact. 2009 Oct 30;181(3):351-8.
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Product Notes
The Phyllanthin (Catalog #AAA5760778) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Phyllanthin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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