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Structure

paricalcitol.D6, Inhibitor

paricalcitol.D6

Purity
98.00%
Synonyms
paricalcitol.D6; inhibitor
Ordering
For Research Use Only!
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C27H38D6O3
SMILES
C[C@]([C@@H]([C@@H](/C=C/[C@@H](C(C([2H])([2H])[2H])(C([2H])([2H])[2H])O)C)C)CC1)(CCC/2)[C@@]1(C2=C\C=C3C[C@H](C[C@@H](C/3)O)O)[H]
Target & IC50
Others
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Structure
Related Product Information for paricalcitol.D6, inhibitor
paricalcitol.D6 is the deuterated form of paricalcitol. which is used for the prevention and treatment,of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
References
Martinez-Moreno JM, Munoz-Castaneda JR, Herencia C, Montes de Oca A, Estepa JC, Canalejo R, Rodriguez-Ortiz ME, Perez-Martinez P, Aguilera-Tejero E, Canalejo A, Rodriguez M, Almaden Y. In vascular smooth muscle cells paricalcitol.prevents phosphate-induced Wnt/beta-catenin activation. Am J Physiol Renal Physiol. 2012 Aug 8.
Martinez-Moreno JM, Munoz-Castaneda JR, Herencia C, Montes de Oca A, Estepa JC, Canalejo R, Rodriguez-Ortiz ME, Perez-Martinez P, Aguilera-Tejero E, Canalejo A, Rodriguez M, Almaden Y. In vascular smooth muscle cells paricalcitol.prevents phosphate-induced Wnt/beta-catenin activation. Am J Physiol Renal Physiol. 2012 Aug 8.
Ari E, Kedrah AE, Alahdab Y, Bulut G, Eren Z, Baytekin O, Odabasi D. Antioxidant and renoprotective effects of paricalcitol.on experimental contrast-induced nephropathy model. Br J Radiol. 2012 Aug;85(1016):1038-43.
Ari E, Kedrah AE, Alahdab Y, Bulut G, Eren Z, Baytekin O, Odabasi D. Antioxidant and renoprotective effects of paricalcitol.on experimental contrast-induced nephropathy model. Br J Radiol. 2012 Aug;85(1016):1038-43.
Meems LM, Cannon MV, Mahmud H, Voors AA, van Gilst WH, Sillje HH, Ruifrok WP, de Boer RA. The vitamin D receptor activator paricalcitol.prevents fibrosis and diastolic dysfunction in a murine model of pressure overload. J Steroid Biochem Mol Biol. 2012 Jul 16;132(3-5):282-289.
Meems LM, Cannon MV, Mahmud H, Voors AA, van Gilst WH, Sillje HH, Ruifrok WP, de Boer RA. The vitamin D receptor activator paricalcitol.prevents fibrosis and diastolic dysfunction in a murine model of pressure overload. J Steroid Biochem Mol Biol. 2012 Jul 16;132(3-5):282-289.
Blanco-Garcia R, Bravo-Lopez JJ, Moreiras-Plaza M, Najera-de la Garza W, Cossio-Annibar C, Beato-Coo L, Rodriguez-Goyanes G. Microalbuminuria, another use for paricalcitol. Our experience in advanced chronic kidney disease. Nefrologia. 2012 May 14;32(3):401-2. doi: 10.3265/Nefrologia.pre2012.Feb.11378.
Blanco-Garcia R, Bravo-Lopez JJ, Moreiras-Plaza M, Najera-de la Garza W, Cossio-Annibar C, Beato-Coo L, Rodriguez-Goyanes G. Microalbuminuria, another use for paricalcitol. Our experience in advanced chronic kidney disease. Nefrologia. 2012 May 14;32(3):401-2. doi: 10.3265/Nefrologia.pre2012.Feb.11378.
Piao SG, Song JC, Lim SW, Chung BH, Choi BS, Yang CW. Protective effect of paricalcitol.on cyclosporine-induced renal injury in rats. Transplant Proc. 2012 Apr;44(3):642-
Piao SG, Song JC, Lim SW, Chung BH, Choi BS, Yang CW. Protective effect of paricalcitol.on cyclosporine-induced renal injury in rats. Transplant Proc. 2012 Apr;44(3):642-5.

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Product Notes

The paricalcitol.D6 (Catalog #AAA5753642) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "paricalcitol.D6, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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