Chemical Structure
OSI-906, Inhibitor
OSI-906
Purity
>98%
Synonyms
OSI-906; OSI906; linsitinib; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Application Notes
Concentration/ Solvent Volume/ Mass
0.1 mM: 23.72 mL (1 mg); 118.62 mL (5 mg); 237.25mL (10 mg)
0.5 mM: 4.74 mL (1 mg); 23.72 mL (5 mg); 47.45 mL (10 mg)
1 mM: 2.37 mL (1 mg); 11.86 mL (5 mg); 23.72 mL (10 mg)
5 mM: 0.47 mL (1 mg); 2.37 mL (5 mg); 4.74 mL (10 mg) (Lot Specific)
0.1 mM: 23.72 mL (1 mg); 118.62 mL (5 mg); 237.25mL (10 mg)
0.5 mM: 4.74 mL (1 mg); 23.72 mL (5 mg); 47.45 mL (10 mg)
1 mM: 2.37 mL (1 mg); 11.86 mL (5 mg); 23.72 mL (10 mg)
5 mM: 0.47 mL (1 mg); 2.37 mL (5 mg); 4.74 mL (10 mg) (Lot Specific)
CAS Number
867160-71-2
Formula
C26H23N5O
SMILES
CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Actions
Inhibitor
Solubility (DMSO)
80 mg/mL (189.8 mM)
Solubility (Ethanol)
Insoluble
Solubility (in vivo)
5%DMSO+40%PEG300+5%Tween80+50%ddH2O (5.93 mg/mL)
Solubility (Water)
Insoluble
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder
Chemical Structure
Chemical Structure
Related Product Information for OSI-906, inhibitor
OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).
References
Nakamura T, .et al. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production, J Med Food, 2018, Jul;21(7):701-708 PMID: 29583066
Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
Takata N, .et al. IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro, In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 PMID: 26956358
Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
Takata N, .et al. IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro, In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 PMID: 26956358
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Product Notes
The OSI-906 (Catalog #AAA385868) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. Concentration/ Solvent Volume/ Mass 0.1 mM: 23.72 mL (1 mg); 118.62 mL (5 mg); 237.25mL (10 mg) 0.5 mM: 4.74 mL (1 mg); 23.72 mL (5 mg); 47.45 mL (10 mg) 1 mM: 2.37 mL (1 mg); 11.86 mL (5 mg); 23.72 mL (10 mg) 5 mM: 0.47 mL (1 mg); 2.37 mL (5 mg); 4.74 mL (10 mg) (Lot Specific). Researchers should empirically determine the suitability of the OSI-906 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OSI-906, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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