ONX-0914, Inhibitor

ONX-0914

Cat. Num. AAA385861

• Purity: >98%
• Synonyms: ONX-0914; ONX0914; ONX 0914; PR-957; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 17.22 mL (1 mg); 86.11 mL (5 mg); 172.21mL (10 mg); 0.5 mM: 3.44 mL (1 mg); 17.22 mL (5 mg); 34.44 mL (10 mg); 1 mM: 1.72 mL (1 mg); 8.61 mL (5 mg); 17.22 mL (10 mg); 5 mM: 0.34 mL (1 mg); 1.72 mL (5 mg); 3.44 mL (10 mg) (varies by lot)

• CAS Number: 960374-59-8
• Formula: C31H40N4O7
• SMILES: C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C)NC(=O)CN4CCOCC4
• Actions: Inhibitor
• Solubility (DMSO): 100 mg/mL (172.21 mM)
• Solubility (Ethanol): 100 mg/mL (172.21 mM)
• Solubility (Water): <1 mg/mL (<1 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for ONX-0914, inhibitor

ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.

References

Ming-Shu Mo, .et al. Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo, Transl Neurodegener, 2018, 7: 19 PMID: 30128145
Ohkusu-Tsukada K, .et al. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice, Int Arch Allergy Immunol, 2018, 176(2):91-100 PMID: 29669333
Arimochi H, .et al. Differentiation of preadipocytes and mature adipocytes requires PSMB8, Sci Rep, 2016, May 26;6:26791 PMID: 27225296