Structure
ONO-5334, Inhibitor
ONO-5334
Purity
>98% (HPLC)
Synonyms
ONO-5334; ONO5334; ONO 5334; inhibitor
Purity/Purification
>98% (HPLC)
Target
Cathepsin
Receptor
Cathepsin
Chemical Name
N-((S)-1-cyclohexyl-3-(2-((R, Z)-3, 4-dimethylthiazolidin-2-ylidene)hydrazinyl)-2, 3-dioxopropyl)cycloheptanecarboxamide
SMILES
O=C(N/N=C1SC[C@@H](C)N1C)C([C@@H](NC(C2CCCCCC2)=O)C3CCOCC3)=O
Molecular Formula
C21H34N4O4S
CAS Number
868273-90-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ONO-5334, inhibitor
A potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1nM, 0.049nM and 0.85nM for human, rabbit and rat cathepsin K, respectively; shows less or no potentcy for human cathepsin S/L/B/C (Ki=0.83/1.7/32/2500nM); inhibits human osteoclasts bone resorption in vitro at a concentration more than 100 fold lower than that of alendronate; reduces plasma calcium level increased by PTHrP in thyroparathyroidectomized rats, decreases serum and urine C-telopeptide of type I collagen level. Osteoporosis Phase 2 Discontinued
Product Categories/Family for ONO-5334, inhibitor
References
1. Ochi Y, et al. Bone. 2011 Dec; 49 (6):1351-6.
2. Ochi Y, et al. Bone. 2014 Aug; 65:1-8. doi: 10.1016/j.bone.2014.04.023.
3. Ochi Y, et al. J Bone Miner Metab. 2014 Nov; 32 (6):645-52.
4. Nagase S, et al. Br J Clin Pharmacol. 2012 Dec; 74 (6):959-70.
2. Ochi Y, et al. Bone. 2014 Aug; 65:1-8. doi: 10.1016/j.bone.2014.04.023.
3. Ochi Y, et al. J Bone Miner Metab. 2014 Nov; 32 (6):645-52.
4. Nagase S, et al. Br J Clin Pharmacol. 2012 Dec; 74 (6):959-70.
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Product Notes
The ONO-5334 (Catalog #AAA3606302) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ONO-5334, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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