O-Phosphorylethanolamine, Inhibitor
O-Phosphorylethanolamine
Purity
98.00%
Synonyms
O-Phosphorylethanolamine; inhibitor
Purity/Purification
98.00%
Form/Format
Powder
Formula
C2H8NO4P
CAS
1071-23-4
Smiles
NCCOP(O)(O)=O
Solubility
DMSO: Soluble
Methanol: Soluble
(<1mg/ml refers to the product slightly soluble or insoluble)
Methanol: Soluble
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Related Product Information for O-Phosphorylethanolamine, inhibitor
Phosphoethanolamine (PE) is a phosphomonoester metabolite of the phospholipid metabolism. PE is a precursor of phospholipid synthesis and a product of phospholipid breakdown. Phosphomonoesters are present at much higher levels in the brain than in other organs. In developing the brain, phosphomonoesters are normally elevated during the period of neuritic proliferation. This also coincides with the occurrence of normal programmed cell death and synaptic pruning in developing the brain. These findings are consistent with the role of phosphomonoesters in membrane biosynthesis. PE shows a strong structural similarity to the inhibitory neurotransmitter, GABA, and the GABAB receptor partial agonist, 3-amino-propylphosphonic acid. PE is a phosphomonoester which is decreased in post-mortem Alzheimer's disease (AD) brain.
References
1. Klunk W E, et al. Inactivity of phosphoethanolamine, an endogenous GABA analog decreased in Alzheimer's disease, at GABA binding sites[J]. Life Sciences, 1995, 56 (26):2377.
2. Klunk W E, et al. Structural determinants of activity at the GABAB receptor. A comparison of phosphoethanolamine and related GABA analogs.[J]. Mol Chem Neuropathol, 1995, 26 (1):15-30.
3. Li G, et al. Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum[J]. Development, 2001, 128 (18):3473-3483.
2. Klunk W E, et al. Structural determinants of activity at the GABAB receptor. A comparison of phosphoethanolamine and related GABA analogs.[J]. Mol Chem Neuropathol, 1995, 26 (1):15-30.
3. Li G, et al. Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum[J]. Development, 2001, 128 (18):3473-3483.
